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Effect of structure and composition of cationic liposomes on the delivery of siRNA in vitro and in vivo

This study explores the effects of the modifications of siRNA delivery systems based on cationic liposomes containing the polycationic amphiphile 2 × 3 and lipid-helper DOPE on their ability to deliver therapeutic siRNA in vitro and in vivo. We supplied the core liposome system with lipoconjugates d...

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Autors principals: Daniil V. Gladkikh, Elena V. Shmendel, Darya M. Makarova, Mikhail A. Maslov, Marina A. Zenkova, Elena L. Chernolovskaya
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2025-09-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2025.1656671/full
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