Generation of an Attenuated Tiantan Vaccinia Virus Strain by Deletion of Multiple Genes

An attenuated vaccinia virus-MVTTEAB-was constructed by deletion of non-essential gene segments related to the immunomodulatory and virulence functions of the vaccinia virus Tiantan strain (VVTT). The shuttle plasmids pTC-EGFP, pTE-EGFP, pTA35-EGFP, pTB-EGFP, and pTA66-EGFP were constructed and comb...

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Bibliografische Detailangaben

Hauptverfasser:	Yiquan Li, Yilong Zhu, Shuang Chen, Wenjie Li, Xunzhe Yin, Shanzhi Li, Pengpeng Xiao, Jicheng Han, Xiao Li, Lili Sun, Ningyi Jin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2017-10-01
Schriftenreihe:	Frontiers in Cellular and Infection Microbiology
Schlagworte:	attenuated vaccinia virus vector homologous recombination vaccinia Tiantan strain virus virulence immunogenicity
Online-Zugang:	http://journal.frontiersin.org/article/10.3389/fcimb.2017.00462/full
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