KV11.1 (hERG1)-centered macromolecular membrane complexes regulate proliferation in B cell lymphomas and constitute novel pharmacological targets

K+ channel modulation is essential to regulate the Ca2+ signals that trigger T and B lymphocyte activation. The K+ channel complement is however deeply altered in cancer cells, as it is implicated in the neoplastic progression. We investigated the functional expression of K+ channels in different di...

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Hauptverfasser:	Cesare Sala, Jessica Iorio, Claudia Duranti, Alberto Montalbano, Laura Clara Grandi, Luciano Cascione, Markus Raderer, Francesco Bertoni, Annarosa Arcangeli, Andrea Becchetti
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-11-01
Schriftenreihe:	Pharmacological Research
Schlagworte:	Clarithromycin Diffuse large B cell lymphoma hELK2 β1 integrin KV12.2 Lymphocytes
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1043661825004177
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