K-Ras Peptide Mimotope Induces Antigen Specific Th1 and B-Cell Immune Responses against G12A-Mutated K-Ras Antigen in Balb/c Mice

<i>KRAS</i> G12A somatic point mutation in adenocarcinomas is categorized clinically as ineligibility criteria for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapies. In this study, a modified G12A-K-ras epitope (139A) with sequence-specific modifications to improve immunogen...

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Autors principals:	Pui Yan Siak, Kuan Yee Wong, Adelene Ai-Lian Song, Raha Abdul Rahim, Lionel Lian Aun In
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-02-01
Col·lecció:	Vaccines
Matèries:	<i>KRAS</i> <i>Lactococcus lactis</i> tetanus toxoid peptide-based vaccine
Accés en línia:	https://www.mdpi.com/2076-393X/9/3/195
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