Codon optimization regulates IgG3 and IgM expression and glycosylation in N. benthamiana

Plants are being increasingly recognized for the production of complex human proteins, including monoclonal antibodies (mAbs). Various methods have been applied to boost recombinant expression, with DNA codon usage being an important approach. Here, we transiently expressed three complex human mAbs...

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Hlavní autoři:	Lin Sun, Somanath Kallolimath, Roman Palt, Florian Eminger, Richard Strasser, Herta Steinkellner
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-12-01
Edice:	Frontiers in Bioengineering and Biotechnology
Témata:	codon usage antibody transcription and translation glycosylation Nicotiana benthamiana
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fbioe.2023.1320586/full
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