KLRG1 re-defines a leukemic clone of CD8 effector T cells sensitive to PI3K inhibitor in T cell large granular lymphocytic leukemia

Summary: T cell large granular lymphocytic leukemia (T-LGLL) is a clonal lymphoproliferative disorder, originated from mature effector memory CD8+ T cells. It is a challenge to define the leukemic T cell clones due to the lack of definite markers. Here, we decipher the heterogeneity of CD8+ T cells...

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Principais autores:	Lele Zhang, Chen Qiu, Ruonan Li, Yucan Shen, Linzhu Tian, Hong Chang, Qian Liang, Hong Pan, Zhen Gao, Weiwang Li, Jingyu Zhao, Liwei Fang, Xiao Yu, Jing Xu, Zhexiang Kuang, Weiping Yuan, Yajing Chu, Jun Shi
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2025-04-01
叢編:	Cell Reports Medicine
主題:	T-LGLL KLRG1 PI3K CITE-seq TCRαβ-seq
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2666379125001090
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