KLRG1 re-defines a leukemic clone of CD8 effector T cells sensitive to PI3K inhibitor in T cell large granular lymphocytic leukemia

Summary: T cell large granular lymphocytic leukemia (T-LGLL) is a clonal lymphoproliferative disorder, originated from mature effector memory CD8+ T cells. It is a challenge to define the leukemic T cell clones due to the lack of definite markers. Here, we decipher the heterogeneity of CD8+ T cells...

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Hlavní autoři:	Lele Zhang, Chen Qiu, Ruonan Li, Yucan Shen, Linzhu Tian, Hong Chang, Qian Liang, Hong Pan, Zhen Gao, Weiwang Li, Jingyu Zhao, Liwei Fang, Xiao Yu, Jing Xu, Zhexiang Kuang, Weiping Yuan, Yajing Chu, Jun Shi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-04-01
Edice:	Cell Reports Medicine
Témata:	T-LGLL KLRG1 PI3K CITE-seq TCRαβ-seq
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666379125001090
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