Microcystin-LR Drives Early NAFLD Pathogenesis via Hepatic Cholesterol Accumulation: Dysregulation of <i>Ldlr</i> and <i>Abcg1</i> Expression Uncoupled from <i>Srebp2</i>

Chronic exposure to the cyanotoxin microcystin-LR is an emerging environmental driver of non-alcoholic fatty liver disease (NAFLD); however, the initiating molecular events at sub-lethal, environmentally relevant concentrations remain elusive. Current safety guidelines focus primarily on acute injur...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Hideaki Kawahara, Yoshihito Koto, Yuuka Hitsuda, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	MDPI AG 2026-02-01
سلاسل:	Toxins
الموضوعات:	microcystin-LR non-alcoholic fatty liver disease (NAFLD) cholesterol homeostasis low-density lipoprotein receptor (LDLR) ATP-binding cassette transporter G1 (ABCG1) protein phosphatase 2A (PP2A)
الوصول للمادة أونلاين:	https://www.mdpi.com/2072-6651/18/2/92
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!