Microcystin-LR Drives Early NAFLD Pathogenesis via Hepatic Cholesterol Accumulation: Dysregulation of <i>Ldlr</i> and <i>Abcg1</i> Expression Uncoupled from <i>Srebp2</i>

Chronic exposure to the cyanotoxin microcystin-LR is an emerging environmental driver of non-alcoholic fatty liver disease (NAFLD); however, the initiating molecular events at sub-lethal, environmentally relevant concentrations remain elusive. Current safety guidelines focus primarily on acute injur...

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Detalhes bibliográficos

Principais autores:	Hideaki Kawahara, Yoshihito Koto, Yuuka Hitsuda, Koichi Kurata, Keisuke Yoshikiyo, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Toxins
Assuntos:	microcystin-LR non-alcoholic fatty liver disease (NAFLD) cholesterol homeostasis low-density lipoprotein receptor (LDLR) ATP-binding cassette transporter G1 (ABCG1) protein phosphatase 2A (PP2A)
Acesso em linha:	https://www.mdpi.com/2072-6651/18/2/92
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