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p53 regulates TGF-β1-induced proliferation and transdifferentiation of pterygium fibroblasts

This study aimed to investigate whether p53 mediates the role of mammalian target of rapamycin （mTOR） signaling in transforming growth factor beta 1 （TGF-β1）-induced proliferation and transdifferentiation of human pterygium fibroblasts （HPFs）. Primary HPFs were isolated and cultured from human ptery...

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Principais autores: HUA Yun, ZHAO Xin-Rong, LIAN Hai-Dong, ZHANG Si-Yao, HAN Huan-Huan, CHEN Dong-Mei, LIU Jia-Lin, GUO Sheng-Hong
Formato: Artigo
Idioma:Inglês
Publicado: Editorial Department of Journal of Sichuan University (Natural Science Edition) 2025-07-01
Series:四川大学学报. 自然科学版
Assuntos:
Pterygium fibroblast
p53
mTOR
Proliferation
Transdifferentiation
Acceso en liña:http://science.scu.edu.cn/thesisDetails#10.19907/j.0490-6756.250041
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