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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation of lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for the majority of cases of childhood ALL, development of res...

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Main Authors: Shilpa Kuttikrishnan, Kodappully S. Siveen, Kirti S. Prabhu, Abdul Quaiyoom Khan, Eiman I. Ahmed, Sabah Akhtar, Tayyiba A. Ali, Maysaloun Merhi, Said Dermime, Martin Steinhoff, Shahab Uddin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
B-Pre-ALL cells
curcumin
apoptosis
signaling
ROS
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00484/full
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