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Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage

IntroductionPlacental trophoblasts contribute to regulatory T (Treg) function via the programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) pathway during normal pregnancy. Decreased expression of PD-L1 in trophoblasts was closely associated with Treg deficiency in the development of pregnancy failur...

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Detaylı Bibliyografya
Asıl Yazarlar: Yonghong Zhang, Huiyan Wang, Panpan Qiu, Jingwen Jiang, Xuhong Wu, Jie Mei, Haixiang Sun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2023-07-01
Seri Bilgileri:Frontiers in Immunology
Konular:
Online Erişim:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180154/full
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