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Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease

Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD) appears to be of pivotal importance for proteostasis within the central nervous system and in neurodegeneration. Neuronal Ceroid Lipofuscinosis (NCL) type 10 is caused by a lack of CTSD leading to a defective autophagi...

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Autori principali: Lisa Gallwitz, Lina Schmidt, André R.A. Marques, Andreas Tholey, Liam Cassidy, Irem Ulku, Gerhard Multhaup, Alessandro Di Spiezio, Paul Saftig
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2022-12-01
Serie:Neurobiology of Disease
Soggetti:
Cathepsin-D
Lysosome
Neuronal ceroid lipofuscinosis 10
Proteolysis
Amyloid beta
Amyloid precursor protein
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996122003114
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