A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17^HI) identifies a subgroup of patients with shorter survival and poor drug response. We uncovered a mechanism, possibly independent of its enzymatic function, characterized by an enhanced expr...

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Detalhes bibliográficos

Principais autores:	Antoine Wagner, Michèle Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Éric P. Allain, Caroline Beaudoin, Sophie Tremblay, Fréderic Courtier, Flora Nguyen Van Long, Isabelle Laverdière, Éric Lévesque, Versha Banerji, Katrina Vanura, Chantal Guillemette
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-05-01
coleção:	Cells
Assuntos:	glycosyltransferase UGT2B17 CLL B cell receptor BTK ZAP70
Acesso em linha:	https://www.mdpi.com/2073-4409/12/9/1295
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