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A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17<sup>HI</sup>) identifies a subgroup of patients with shorter survival and poor drug response. We uncovered a mechanism, possibly independent of its enzymatic function, characterized by an enhanced expr...

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Principais autores: Antoine Wagner, Michèle Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Éric P. Allain, Caroline Beaudoin, Sophie Tremblay, Fréderic Courtier, Flora Nguyen Van Long, Isabelle Laverdière, Éric Lévesque, Versha Banerji, Katrina Vanura, Chantal Guillemette
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-05-01
Serier:Cells
Fag:
glycosyltransferase
UGT2B17
CLL
B cell receptor
BTK
ZAP70
Online adgang:https://www.mdpi.com/2073-4409/12/9/1295
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