Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Abstract Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA...

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Autors principals:	Thomas Larrieu, Fabio Grieco, Charline Carron, Marta Vilademunt, Crystal Weber, Kyllian Ginggen, Aurélie Delacrétaz, Hector Gallart-Ayala, Mumeko C. Tsuda, Heather A. Cameron, Chin B. Eap, Julijana Ivanisevic, Pierre Magistretti, Evgenia Salta, Giorgia Tosoni, Dilara Ayyildiz, Ludovic Telley, Alexandre Dayer, Camille Piguet, Nicolas Toni
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-02-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-69240-3
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