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Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells

Background: Endothelial function significantly depends on the proteolytic release of surface expressed signal molecules, their receptors and adhesion molecules via the metalloproteinase ADAM17. The pseudoproteases iRhom1 and 2 independently function as adapter proteins for ADAM17 and are essential f...

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Principais autores: Aaron Babendreyer, Diana M. Rojas-González, Anja Adelina Giese, Sandra Fellendorf, Stefan Düsterhöft, Petra Mela, Andreas Ludwig
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-12-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
ADAM
metalloprotease
iRhom1/2 (inactive Rhomboid like protein 1/2)
endothelial cell
vascular inflammation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2020.610344/full
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