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Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory diseases and cancer. Nevertheless, the development...

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Principais autores: Matteo Calligaris, Doretta Cuffaro, Simone Bonelli, Donatella Pia Spanò, Armando Rossello, Elisa Nuti, Simone Dario Scilabra
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-02-01
Serier:Molecules
Fag:
ectodomain shedding
ADAM17
iRhoms
metalloproteinases
TIMPs
TNF
Online adgang:https://www.mdpi.com/1420-3049/26/4/944
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