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Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system

Abstract The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fr...

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Sábháilte in:
Príomhchruthaitheoirí: Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2024-09-01
Sraith:Scientific Reports
Ábhair:
Polygoni Multiflori Radix
Genotoxicity
Ames test
Aroclor 1254-induced rat liver S9
Human liver S9
Metabolic activation system
Rochtain ar líne:https://doi.org/10.1038/s41598-024-72283-5
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