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Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice

Polygoni Multiflori Radix (PM) and Rhei radix et rhizoma (rhubarb) contain similar hepatocyte-toxic anthraquinones such as emodin (major free anthraquinone in PM), physcion and their glycosides. In clinical practice, PM hepatotoxicity has been widely reported, although rhubarb is not recognized as h...

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Principais autores: Shixiao Wang, Xiang Kong, Ning Chen, Pengwei Hu, Hamza Boucetta, Zhaoliang Hu, Xin Xu, Pei Zhang, Xiang Zhan, Ming Chang, Rui Cheng, Wei Wu, Min Song, Yuting Lu, Taijun Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-10-01
coleção:Frontiers in Pharmacology
Assuntos:
Polygoni multiflori radix
rhei radix et rhizoma
toxicology
hepatotoxicity
tissue distribution
correlation analysis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.1007284/full
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