Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer’s disease

Abstract Clinical evidences indicate that multifaceted gait abnormalities may manifest in Alzheimer’s disease (AD) patients, which are associated with cognitive decline. Although the correlation between hippocampal theta power and locomotion has been known for a long time, the mechanisms by how hipp...

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Hlavní autoři:	Hong Ni, Zhongzhao Guo, Jie Wang, Zilu Zhu, Chenyi Xia, Ming Xu, Guohui Zhang, Deheng Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-03-01
Edice:	Scientific Reports
Témata:	Alzheimer’s disease 5xFAD mouse Gait Hippocampus Theta oscillations
On-line přístup:	https://doi.org/10.1038/s41598-025-95585-8
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