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Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer’s disease

Abstract Clinical evidences indicate that multifaceted gait abnormalities may manifest in Alzheimer’s disease (AD) patients, which are associated with cognitive decline. Although the correlation between hippocampal theta power and locomotion has been known for a long time, the mechanisms by how hipp...

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Bibliografiska uppgifter
Huvudupphov: Hong Ni, Zhongzhao Guo, Jie Wang, Zilu Zhu, Chenyi Xia, Ming Xu, Guohui Zhang, Deheng Wang
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2025-03-01
Serie:Scientific Reports
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Länkar:https://doi.org/10.1038/s41598-025-95585-8
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