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Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

ABSTRACT Targeted protein degradation (TPD) offers powerful therapeutic opportunities but is limited by poor tissue penetration and E3 ligase dependence. Herein, we develop Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC), an ultrasound (US)‐activated, bioorthogonal strategy for in situ protein...

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Kaydedildi:
Asıl Yazarlar: Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2026-02-01
Seri Bilgileri:Advanced Science
Konular:
bioorthogonal chemistry
SDPTAC
sonodynamic therapy
targeted protein degradation
Online Erişim:https://doi.org/10.1002/advs.202520975
Etiketler: Etiketle
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