Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and principles of G-protein coupling and selectivity on...
Na minha lista:
| Principais autores: | , , , , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-09-01
|
| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-022-33173-4 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|