Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling

Abstract Many orphan G protein-coupled receptors (GPCRs) remain understudied because their endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like orphan GPCRs including GPR61, GPR161 and GPR174 increase the cAMP level similarly to fully activated D1 dopamine receptor (D...

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Principais autores:	Yingying Nie, Zeming Qiu, Sijia Chen, Zhao Chen, Xiaocui Song, Yan Ma, Niu Huang, Jason G. Cyster, Sanduo Zheng
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2023-09-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-023-41654-3
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