Inhibition of HIV-1 replication by primer RNA packaging inhibitors

ABSTRACT An essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1) is the packaging of tRNA3Lys during viral assembly. This step, which requires the assembly of a ternary complex consisting of GagPol, mitochondrial lysyl-tRNA synthetase, and tRNA3Lys, is essential for the pr...

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Autors principals:	Marc Mirande, Frédéric Subra, Clémence Richetta, Eric Deprez, Olivier Delelis
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-11-01
Col·lecció:	mBio
Matèries:	human immunodeficiency virus integrase host-pathogen interactions lysyl-tRNA synthetase lacidipine azelastine
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.02087-25
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