Network propagation of rare variants in Alzheimer's disease reveals tissue-specific hub genes and communities.

State-of-the-art rare variant association testing methods aggregate the contribution of rare variants in biologically relevant genomic regions to boost statistical power. However, testing single genes separately does not consider the complex interaction landscape of genes, nor the downstream effects...

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מידע ביבליוגרפי

Principais autores:	Marzia Antonella Scelsi, Valerio Napolioni, Michael D Greicius, Andre Altmann, Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Alzheimer’s Disease Sequencing Project (ADSP)
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2021-01-01
סדרה:	PLoS Computational Biology
גישה מקוונת:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008517&type=printable
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