Network propagation of rare variants in Alzheimer's disease reveals tissue-specific hub genes and communities.

State-of-the-art rare variant association testing methods aggregate the contribution of rare variants in biologically relevant genomic regions to boost statistical power. However, testing single genes separately does not consider the complex interaction landscape of genes, nor the downstream effects...

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Autori principali:	Marzia Antonella Scelsi, Valerio Napolioni, Michael D Greicius, Andre Altmann, Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Alzheimer’s Disease Sequencing Project (ADSP)
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2021-01-01
Serie:	PLoS Computational Biology
Accesso online:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008517&type=printable
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