Urolithin A enhances mitochondrial biogenesis-related markers and maximal respiratory capacity during C2C12 differentiation

IntroductionSkeletal muscle differentiation in the C2C12 myoblast model requires extensive mitochondrial remodeling to meet rising bioenergetic demands through coordinated changes in biogenesis, dynamics, and respiratory adaptation. Urolithin A (UA), a gut microbiota-derived metabolite of ellagitann...

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Principais autores:	Ronald Vargas-Foitzick, Diego Irribarra-Tapia, Mayalen Valero-Breton, Elisa Balboa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
Colecção:	Frontiers in Cell and Developmental Biology
Assuntos:	C2C12 myotubes maximal respiration myogenic differentiation oxphos urolithin A
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1854844/full
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