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The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific

CD8+ T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural protein that is prone to mutations, threatening the efficacy...

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Principais autores: You Min Ahn, Janesha C. Maddumage, Emma J. Grant, Demetra S.M. Chatzileontiadou, W.W.J. Gihan Perera, Brian M. Baker, Christopher Szeto, Stephanie Gras
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-01-01
coleção:Current Research in Structural Biology
Assuntos:
X-ray crystallography
SARS-CoV-2
T cells
Viral epitopes
HLA
Viral mutation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2665928X24000254
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