Genomic data analysis workflows for tumors from patient-derived xenografts (PDXs): challenges and guidelines

Abstract Background Patient-derived xenograft (PDX) models are in vivo models of human cancer that have been used for translational cancer research and therapy selection for individual patients. The Jackson Laboratory (JAX) PDX resource comprises 455 models originating from 34 different primary site...

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Autori principali:	Xing Yi Woo, Anuj Srivastava, Joel H. Graber, Vinod Yadav, Vishal Kumar Sarsani, Al Simons, Glen Beane, Stephen Grubb, Guruprasad Ananda, Rangjiao Liu, Grace Stafford, Jeffrey H. Chuang, Susan D. Airhart, R. Krishna Murthy Karuturi, Joshy George, Carol J. Bult
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-07-01
Serie:	BMC Medical Genomics
Soggetti:	Patient-derived xenografts DNA sequencing RNA sequencing SNP array Somatic mutation Gene expression
Accesso online:	http://link.springer.com/article/10.1186/s12920-019-0551-2
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