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Comprehensive DNA profiling strategy for patient-derived xenograft model authentication in the J-PDX library

Abstract Patient-derived xenograft models are crucial in cancer research, although authentication methods remain limited. This study developed a comprehensive DNA profiling strategy for patient-derived xenograft quality control in the J-PDX Library by comparing short tandem repeat and single nucleot...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Tomomi Yoshino, Shigehiro Yagishita, Mami Takahashi, Chiaki Ushie, Ako Takahashi, Yasushi Yatabe, Shinji Kohsaka, Toshihide Ueno, Hanako Ono, Kouya Shiraishi, Akinobu Hamada
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2025-11-01
Rangatū:Scientific Reports
Ngā marau:
Patient-derived xenograft
Short tandem repeat
Single nucleotide polymorphism
Quality control
Authentication
J-PDX Library
Urunga tuihono:https://doi.org/10.1038/s41598-025-21299-6
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