Comprehensive DNA profiling strategy for patient-derived xenograft model authentication in the J-PDX library

Abstract Patient-derived xenograft models are crucial in cancer research, although authentication methods remain limited. This study developed a comprehensive DNA profiling strategy for patient-derived xenograft quality control in the J-PDX Library by comparing short tandem repeat and single nucleot...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Tomomi Yoshino, Shigehiro Yagishita, Mami Takahashi, Chiaki Ushie, Ako Takahashi, Yasushi Yatabe, Shinji Kohsaka, Toshihide Ueno, Hanako Ono, Kouya Shiraishi, Akinobu Hamada
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Portfolio 2025-11-01
श्रृंखला:	Scientific Reports
विषय:	Patient-derived xenograft Short tandem repeat Single nucleotide polymorphism Quality control Authentication J-PDX Library
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41598-025-21299-6
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