Optimizing HDAC inhibitors to enhance HDR-associated CRISPR-Cas9 gene editing efficiency in vivo and in vitro

Gene editing by CRISPR-Cas9 via homology-directed repair (HDR) offers precise and desirable modifications, but its low efficiency remains a challenge due to the dominance of the non-homologous end joining (NHEJ) pathway in DNA repair. To identify compounds that improve HDR-associated gene editing ef...

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Hlavní autoři:	Jeong Woon Jang, Min Ji Kim, Chang Sik Cho, Jun Hee Han, Sangsu Bae, Hongjun Jeon, Dong Hyun Jo, Hye Jin Nam
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-03-01
Edice:	Heliyon
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2405844025013520
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