Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes

Multifunctional factor progranulin (PGRN) plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD). The first breakthrough in understanding the molecular mechanisms of P...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Jinlong Jian, Aubryanna Hettinghouse, Chuan-ju Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	KeAi Communications Co., Ltd. 2017-09-01
Edice:	Genes and Diseases
Témata:	β-glucocerebrosidase Cathepsin D Chaperone Lysosomal storage diseases Lysosomal trafficking Progranulin
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2352304217300363
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!