Rational design of thrombin-derived VFR12 analogs with enhanced antimicrobial, antibiofilm, and anti-inflammatory properties
Abstract The worsening crisis of antibiotic resistance demands innovative therapies to combat multidrug-resistant pathogens. In this study, we report the rational design and optimization of VFR12 (VFRLKKWIQKVI), a thrombin C-terminus-derived 12-mer peptide, via systematic amino acid substitutions an...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Portfolio
2025-11-01
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| Seri Bilgileri: | Scientific Reports |
| Konular: | |
| Online Erişim: | https://doi.org/10.1038/s41598-025-24789-9 |
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