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Design and evaluation of octopromycin-derived peptides as multifunctional antimicrobial agents against multidrug-resistant pathogens

Abstract Octopromycin (OPM), an antimicrobial peptide from Octopus minor, shows potent activity against multidrug-resistant (MDR) Acinetobacter baumannii. Guided by the structure–activity relationship of the N-terminal domain OPM23, we designed short α-helical peptides with enhanced antimicrobial, a...

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Principais autores: Byambasuren Ganbaatar, Sukumar Dinesh Kumar, Eun Young Kim, Naveen Kumar Radhakrishnan, Sungtae Yang, Song Yub Shin, Chul Won Lee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-11-01
Serier:Scientific Reports
Fag:
Antimicrobial peptide
OPM23
Antimicrobial activity
Anti-inflammatory activity
Antibiofilm activity
Protease stability
Online adgang:https://doi.org/10.1038/s41598-025-25213-y
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