Biomanufacturing and lipidomics analysis of extracellular vesicles secreted by human blood vessel organoids in a vertical wheel bioreactor

Abstract Background Extracellular vesicles (EVs) derived from human organoids are phospholipid bilayer-bound nanoparticles that carry therapeutic cargo. However, the low yield of EVs remains a critical bottleneck for clinical translation. Vertical-Wheel bioreactors (VWBRs), with unique design featur...

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Detalhes bibliográficos

Principais autores:	Justice Ene, Chang Liu, Falak Syed, Li Sun, Danyale Berry, Pradeepraj Durairaj, Zixiang Leonardo Liu, Changchun Zeng, Sunghoon Jung, Yan Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-04-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Human blood vessel organoids Extracellular vesicles Vertical wheel bioreactor Aggregates Microcarriers Lipidomics
Acesso em linha:	https://doi.org/10.1186/s13287-025-04317-2
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