Biomanufacturing and lipidomics analysis of extracellular vesicles secreted by human blood vessel organoids in a vertical wheel bioreactor

Abstract Background Extracellular vesicles (EVs) derived from human organoids are phospholipid bilayer-bound nanoparticles that carry therapeutic cargo. However, the low yield of EVs remains a critical bottleneck for clinical translation. Vertical-Wheel bioreactors (VWBRs), with unique design featur...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Justice Ene, Chang Liu, Falak Syed, Li Sun, Danyale Berry, Pradeepraj Durairaj, Zixiang Leonardo Liu, Changchun Zeng, Sunghoon Jung, Yan Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-04-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Human blood vessel organoids Extracellular vesicles Vertical wheel bioreactor Aggregates Microcarriers Lipidomics
Online-Zugang:	https://doi.org/10.1186/s13287-025-04317-2
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!