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Are Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed

A versatile family of quaternary propargylamines was synthesized employing the KA<sup>2</sup> multicomponent reaction, through the single-step coupling of a number of amines, ketones, and terminal alkynes. Sustainable synthetic procedures using transition metal catalysts were employed in all cases....

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Principais autores: Panagiou Mavroeidi, Leandros P. Zorba, Nikolaos V. Tzouras, Stavros P. Neofotistos, Nikitas Georgiou, Kader Sahin, Murat Şentürk, Serdar Durdagi, Georgios C. Vougioukalakis, Thomas Mavromoustakos
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-05-01
coleção:Molecules
Assuntos:
propargylamines
molecular dynamics
MM/GBSA
monoaminoxidases
Acesso em linha:https://www.mdpi.com/1420-3049/29/11/2486
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