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Intranasal Treatment with Cannabinoid 2 Receptor Agonist HU-308 Ameliorates Cold Sensitivity in Mice with Traumatic Trigeminal Neuropathic Pain

Post-traumatic trigeminal neuropathy (PTTN) is a sensory abnormality caused by injury to the trigeminal nerve during orofacial surgery. However, existing analgesics are ineffective against PTTN. Abnormal microglial activation in the caudal part of the spinal trigeminal nucleus caudal part (Sp5C), wh...

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Principais autores: Simeng Ma, Yoki Nakamura, Suzuna Uemoto, Kenta Yamamoto, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-11-01
Serier:Cells
Fag:
cannabinoid receptor 2
cold sensitivity
intranasal treatment
post-traumatic trigeminal neuropathy
microglia
Online adgang:https://www.mdpi.com/2073-4409/13/23/1943
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