Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis

Abstract Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such changes occur in knee OA mice and their association w...

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Auteurs principaux:	Ryo Miyake, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamada
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-08-01
Collection:	Molecular Brain
Sujets:	Osteoarthritis of the knee Chronic pain Synaptic plasticity Anterior cingulate cortex Exercise therapy Voluntary running
Accès en ligne:	https://doi.org/10.1186/s13041-025-01207-9
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