Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis

Abstract Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such changes occur in knee OA mice and their association w...

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Detalhes bibliográficos

Principais autores:	Ryo Miyake, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamada
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Molecular Brain
Assuntos:	Osteoarthritis of the knee Chronic pain Synaptic plasticity Anterior cingulate cortex Exercise therapy Voluntary running
Acesso em linha:	https://doi.org/10.1186/s13041-025-01207-9
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