Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e., are largely confined to the activating cell...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-06-01
Colecção:	Frontiers in Pharmacology
Assuntos:	nitroreductase (NTR) bystander effect targeted cell ablation enzyme-prodrug therapy GDEPT BDEPT
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2021.701456/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!