Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

Bacterial nitroreductase enzymes that can efficiently convert nitroaromatic prodrugs to a cytotoxic form have numerous applications in targeted cellular ablation. For example, the generation of cytotoxic metabolites that have low bystander potential (i.e., are largely confined to the activating cell...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Abigail V. Sharrock, Sarah P. McManaway, Michelle H. Rich, Jeff S. Mumm, Ian F. Hermans, Moana Tercel, Frederik B. Pruijn, David F. Ackerley
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-06-01
Σειρά:	Frontiers in Pharmacology
Θέματα:	nitroreductase (NTR) bystander effect targeted cell ablation enzyme-prodrug therapy GDEPT BDEPT
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fphar.2021.701456/full
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