The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

Abstract Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with a 61.9% overall survival rate, metastatic disease is often f...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Imad Soukar, Robert J. Fisher, Sanjana Bhagavatula, Marianne Collard, Philip A. Cole, Rhoda M. Alani
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2025-03-01
Sarja:	Scientific Reports
Aiheet:	CoREST Corin HDAC LSD1 MPNST Epigenetics
Linkit:	https://doi.org/10.1038/s41598-025-94517-w
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