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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors

Abstract Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with a 61.9% overall survival rate, metastatic disease is often f...

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Autori principali: Imad Soukar, Robert J. Fisher, Sanjana Bhagavatula, Marianne Collard, Philip A. Cole, Rhoda M. Alani
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-03-01
Serie:Scientific Reports
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Accesso online:https://doi.org/10.1038/s41598-025-94517-w
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