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Repurposing Cefazolin-Avibactam for the Treatment of Drug Resistant Mycobacterium tuberculosis

Background: While tuberculosis (TB) is curable and preventable, the most effective first-line antibiotics cannot kill multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb). Therefore, effective drugs are needed to combat MDR-TB, especially in children. Our objective was to repurpose cefazolin...

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Principais autores: Shashikant Srivastava, Tawanda Gumbo, Tania Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-10-01
Serier:Frontiers in Pharmacology
Fag:
beta-lactam
cephalosporin
avibactam
optimal dose
multidrug resistant tuberculosis
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.776969/full
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