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Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells

Modulation of global mRNA translation, which is essential for intestinal stem cell function, is controlled by Wnt signaling. Loss of tumor supressor APC in stem cells drives adenoma formation through hyperactivion of Wnt signaling and dysregulated translational control. It is unclear whether factors...

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Principais autores: W.L. Smit, R.J. de Boer, B.J. Meijer, C.N. Spaan, M. van Roest, P.J. Koelink, J. Koster, E. Dekker, T.E.M. Abbink, M.S. van der Knaap, G.R. van den Brink, V. Muncan, J. Heijmans
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-08-01
Serier:Stem Cell Research
Fag:
eIF2B epsilon
Global mRNA translation
Wnt signaling
APC
Intestinal stemness
Online adgang:http://www.sciencedirect.com/science/article/pii/S1873506121003469
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