Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients and shows an RLS-like behavioral phenotype. Previou...

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Detalhes bibliográficos

Principais autores:	Matilde S. Rodrigues, Samira G. Ferreira, César Quiroz, Christopher J. Earley, Diego García-Borreguero, Rodrigo A. Cunha, Francisco Ciruela, Attila Köfalvi, Sergi Ferré
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-02-01
coleção:	Molecules
Assuntos:	adenosine A<sub>1</sub> receptor adenosine A<sub>2A</sub> receptor restless legs syndrome brain iron deficiency striatum cortico-striatal terminals
Acesso em linha:	https://www.mdpi.com/1420-3049/27/5/1489
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